A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells

Synaptotagmin-1 (Syt1) is the principal Ca(2+) sensor for vesicle fusion and is also essential for vesicle docking in chromaffin cells. Docking depends on interactions of the Syt1-C2B domain with the t-SNARE SNAP25/Syntaxin1 complex and/or plasma membrane phospholipids. Here, we investigated the rol...

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Publicat a:J Neurosci
Autors principals: Kedar, Girish H., Munch, Anders S., van Weering, Jan R.T., Malsam, Jörg, Scheutzow, Andrea, de Wit, Heidi, Houy, Sébastien, Tawfik, Bassam, Söllner, Thomas H., Sørensen, Jakob B., Verhage, Matthijs
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605428/
https://ncbi.nlm.nih.gov/pubmed/26490858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1911-15.2015
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