Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission

Whether interactions between synaptotagmin-1 (syt-1) and the soluble NSF attachment protein receptors (SNAREs) are required during neurotransmission is debated. We examined five SNAP-25 mutations designed to interfere with syt-1 interactions. One mutation, D51/E52/E55A, targeted negative charges wit...

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Publicat a:J Neurosci
Autors principals: Schupp, Melanie, Malsam, Jörg, Ruiter, Marvin, Scheutzow, Andrea, Wierda, Keimpe D.B., Söllner, Thomas H., Sørensen, Jakob B.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604916/
https://ncbi.nlm.nih.gov/pubmed/27881774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1011-16.2016
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