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Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca(2+) and SNAREs. Whether Doc2B functions as a calcium sensor akin to synaptotagmins, or in other calcium-independent or calcium-dependent capacities is debate...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Houy, Sébastien, Groffen, Alexander J, Ziomkiewicz, Iwona, Verhage, Matthijs, Pinheiro, Paulo S, Sørensen, Jakob Balslev
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758110/
https://ncbi.nlm.nih.gov/pubmed/29274147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27000
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