Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis

Pyruvate dehydrogenase kinases (PDK1–4) are mitochondrial metabolic regulators that serve as decision makers via modulation of pyruvate dehydrogenase (PDH) activity to convert pyruvate either aerobically to acetyl-CoA or anaerobically to lactate. Metabolic dysregulation and inflammatory processes ar...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Jha, Mithilesh Kumar, Song, Gyun Jee, Lee, Maan Gee, Jeoung, Nam Ho, Go, Younghoon, Harris, Robert A., Park, Dong Ho, Kook, Hyun, Lee, In-Kyu, Suk, Kyoungho
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605420/
https://ncbi.nlm.nih.gov/pubmed/26490872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1910-15.2015
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