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The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage

Proteinase cascades are part of the basic machinery of neuronal death pathways. Neuronal cathepsin B (CatB), a typical cysteine lysosomal protease, plays a critical role in neuronal death through lysosomal leakage or excessive autophagy. On the other hand, much attention has been paid to microglial...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ni, Junjun, Wu, Zhou, Peterts, Christoph, Yamamoto, Kenji, Qing, Hong, Nakanishi, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605404/
https://ncbi.nlm.nih.gov/pubmed/26354916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1599-15.2015
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