Spinocerebellar Ataxia Type 6 Protein Aggregates Cause Deficits in Motor Learning and Cerebellar Plasticity

Spinocerebellar ataxia type 6 (SCA6) is linked to poly-glutamine (polyQ) within the C terminus (CT) of the pore-forming subunits of P/Q-type Ca(2+) channels (Ca(v)2.1) and is characterized by CT protein aggregates found in cerebellar Purkinje cells (PCs). One hypothesis regarding SCA6 disease is tha...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Mark, Melanie D., Krause, Martin, Boele, Henk-Jan, Kruse, Wolfgang, Pollok, Stefan, Kuner, Thomas, Dalkara, Deniz, Koekkoek, Sebastiaan, De Zeeuw, Chris I., Herlitze, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605201/
https://ncbi.nlm.nih.gov/pubmed/26063920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0891-15.2015
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