Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease

Soluble amyloid-β (Aβ) oligomers, also known as Aβ-derived diffusible ligands (ADDLs), are thought to be the key pathogenic factor in Alzheimer's disease (AD), but there is still no effective treatment for preventing or reversing the progression of the disease. Targeting NMDA receptor trafficki...

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Vydáno v:J Neurosci
Hlavní autoři: Shi, Xiao-Dong, Sun, Kai, Hu, Rui, Liu, Xiao-Ya, Hu, Qiu-Mei, Sun, Xiao-Yu, Yao, Bin, Sun, Nan, Hao, Jing-Ru, Wei, Pan, Han, Yuan, Gao, Can
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604917/
https://ncbi.nlm.nih.gov/pubmed/27881781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1327-16.2016
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