Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathwaysas Targetable Vulnerabilities in Breast Cancer

Most cancer cells exhibit metabolic flexibility, enabling them to withstand fluctuations in intratumoral concentrations of glucose (and other nutrients) and changes in oxygen availability. While these adaptive responses make it difficult to achieve clinically useful anti-tumor responses when targeti...

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Pubblicato in:Cell Rep
Autori principali: Park, Sunghee, Safi, Rachid, Liu, Xiaojing, Baldi, Robert, Liu, Wen, Liu, Juan, Locasale, Jason W., Chang, Ching-yi, McDonnell, Donald P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604861/
https://ncbi.nlm.nih.gov/pubmed/31216477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.066
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