Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathwaysas Targetable Vulnerabilities in Breast Cancer

Most cancer cells exhibit metabolic flexibility, enabling them to withstand fluctuations in intratumoral concentrations of glucose (and other nutrients) and changes in oxygen availability. While these adaptive responses make it difficult to achieve clinically useful anti-tumor responses when targeti...

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Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Park, Sunghee, Safi, Rachid, Liu, Xiaojing, Baldi, Robert, Liu, Wen, Liu, Juan, Locasale, Jason W., Chang, Ching-yi, McDonnell, Donald P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604861/
https://ncbi.nlm.nih.gov/pubmed/31216477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.05.066
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