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Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

BACKGROUND: Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation. TNFα–TNF receptor-1 (TNFR1) signaling contributes to the pathological processe...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Saddala, Madhu Sudhana, Huang, Hu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604280/
https://ncbi.nlm.nih.gov/pubmed/31266509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1965-5
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