p16(INK4A)-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation

BACKGROUND: The therapeutic benefits of mesenchymal stromal cells (MSCs) include treatment of chronic inflammation. However, given the short-lived engraftment of these cells in vivo, their therapeutic efficacy remains mysterious. Transient induction of cellular senescence contributes to activation o...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Chikenji, Takako S., Saito, Yuki, Konari, Naoto, Nakano, Masako, Mizue, Yuka, Otani, Miho, Fujimiya, Mineko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604166/
https://ncbi.nlm.nih.gov/pubmed/31129096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.012
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