Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways

BACKGROUND: We previously demonstrated the gut microbes-derived metabolite trimethylamine N-oxide (TMAO) could activate the atrial autonomic ganglion plexus and promote atrial arrhythmia. The cardiac sympathetic nervous system (CSNS) play important roles in modulating ventricular arrhythmia (VA). ME...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Meng, Guannan, Zhou, Xiaoya, Wang, Menglong, Zhou, Liping, Wang, Zhenya, Wang, Meng, Deng, Jielin, Wang, Yuhong, Zhou, Zhen, Zhang, Yifeng, Lai, Yanqiu, Zhang, Qianqian, Yang, Xiaomeng, Yu, Lilei, Jiang, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6603492/
https://ncbi.nlm.nih.gov/pubmed/30954457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.066
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