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Therapeutic targeting of transcriptional cyclin-dependent kinases

The fact that many cancer types display transcriptional addiction driven by dysregulation of oncogenic enhancers and transcription factors has led to increased interest in a group of protein kinases, known as transcriptional cyclin dependent kinases (tCDKs), as potential therapeutic targets. Despite...

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Pubblicato in:Transcription
Autori principali: Galbraith, Matthew D., Bender, Heather, Espinosa, Joaquín M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602565/
https://ncbi.nlm.nih.gov/pubmed/30409083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2018.1539615
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