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Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery
The transcription cycle of RNA polymerase II (Pol II) is regulated by a set of cyclin-dependent kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK-activa...
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| Publicado no: | Transcription |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6602562/ https://ncbi.nlm.nih.gov/pubmed/30488763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2018.1553483 |
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