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Why minimal is not optimal: Driving the mammalian cell cycle—and drug discovery—with a physiologic CDK control network
Progression through the eukaryotic cell division cycle is governed by the activity of cyclin-dependent kinases (CDKs). For a CDK to become active it must (1) bind a positive regulatory subunit (cyclin) and (2) be phosphorylated on its activation (T) loop. In metazoans, multiple CDK catalytic subunit...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Landes Bioscience
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3409006/ https://ncbi.nlm.nih.gov/pubmed/22732498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20758 |
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