An one-pot two-step automated synthesis of [(18)F]T807 injection, its biodistribution in mice and monkeys, and a preliminary study in humans

[(18)F]T807 is a potent tau protein imaging agent. In order to fulfill the demand from preclinical and clinical studies, we developed an automated one-pot two-step synthesis of this potent tau imaging agent and studied its stability, and dosimetry in mice and monkeys. We also conducted a preliminary...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Huang, Ya-Yao, Chiu, Ming-Jang, Yen, Ruoh-Fang, Tsai, Chia-Ling, Hsieh, Hao-Yu, Chiu, Ching-Hung, Wu, Chi-Han, Hsin, Ling-Wei, Tzen, Kai-Yuan, Cheng, Cheng-Yi, Ma, Kuo-Hsing, Shiue, Chyng-Yann
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602418/
https://ncbi.nlm.nih.gov/pubmed/31260447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217384
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