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Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma
The type I intermediate filament keratin 16 (KRT16 gene; K16 protein) is constitutively expressed in ectoderm-derived appendages and in palmar/plantar epidermis and is robustly induced when the epidermis experiences chemical, mechanical or environmental stress. Missense mutations at the KRT16 locus...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6602407/ https://ncbi.nlm.nih.gov/pubmed/31220272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz050 |
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