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Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma:New insight into skin epithelial homeostasis and avenues for treatment

Pachyonychia congenita (PC), a rare genodermatosis, primarily affects ectoderm-derived epithelial appendages and typically includes oral leukokeratosis, nail dystrophy, and very painful palmoplantar keratoderma (PPK). PC dramatically impacts quality of life though it does not affect lifespan. PC can...

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Detalhes bibliográficos
Publicado no:Br J Dermatol
Main Authors: Zieman, A. G., Coulombe, P. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814456/
https://ncbi.nlm.nih.gov/pubmed/31021398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjd.18033
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