Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity

LAG1 was the first longevity assurance gene discovered in Saccharomyces cerevisiae. The Lag1 protein is a ceramide synthase and its homolog, Lac1, has a similar enzymatic function but no role in aging. Lag1 and Lac1 lie in an enzymatic branch point of the sphingolipid pathway that is interconnected...

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Bibliografski detalji
Izdano u:J Cell Sci
Glavni autori: Megyeri, Márton, Prasad, Rupali, Volpert, Giora, Sliwa-Gonzalez, Andrzej, Haribowo, A. Galih, Aguilera-Romero, Auxiliadora, Riezman, Howard, Barral, Yves, Futerman, Anthony H., Schuldiner, Maya
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602303/
https://ncbi.nlm.nih.gov/pubmed/31164445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.228411
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