Loss of function Cbl-c mutations in solid tumors

Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and progression. Cbl proteins (Cbl, Cbl-b and Cbl-c) are a family of RING finger (RF) ubiquitin ligases that negatively regulate a variety of RTKs, inc...

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Udgivet i:PLoS One
Main Authors: Daniels, Silvano Rakeem, Liyasova, Mariya, Kales, Stephen C., Nau, Marion M., Ryan, Philip E., Green, Jeffrey E., Lipkowitz, Stanley
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602201/
https://ncbi.nlm.nih.gov/pubmed/31260484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219143
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