Loss of function Cbl-c mutations in solid tumors

Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and progression. Cbl proteins (Cbl, Cbl-b and Cbl-c) are a family of RING finger (RF) ubiquitin ligases that negatively regulate a variety of RTKs, inc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Daniels, Silvano Rakeem, Liyasova, Mariya, Kales, Stephen C., Nau, Marion M., Ryan, Philip E., Green, Jeffrey E., Lipkowitz, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602201/
https://ncbi.nlm.nih.gov/pubmed/31260484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219143
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