Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multi-stage, systems biology approach to elucidate disease mechanisms in frontotemporal dementia (FTD). We identify two gene co-expression modules that are preserv...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Swarup, Vivek, Hinz, Flora I., Rexach, Jessica E., Noguchi, Ken-ichi, Toyoshiba, Hiroyoshi, Oda, Akira, Hirai, Keisuke, Sarkar, Arjun, Seyfried, Nicholas T., Cheng, Chialin, Haggarty, Stephen J., Grossman, Murray, Van Deerlin, Vivianna M., Trojanowski, John Q., Lah, James J., Levey, Allan I., Kondou, Shinichi, Geschwind, Daniel H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602064/
https://ncbi.nlm.nih.gov/pubmed/30510257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0223-3
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