Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity

Growth-associated protein 43 (GAP43), a protein kinase C (PKC)-activated phosphoprotein, is often implicated in axonal plasticity and regeneration. In this study, we found that GAP43 can be induced by the endotoxin lipopolysaccharide (LPS) in rat brain astrocytes both in vivo and in vitro. The LPS-i...

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Udgivet i:J Neurosci
Main Authors: Hung, Chia-Chi, Lin, Chun-Hua, Chang, Hsuan, Wang, Chen-Yu, Lin, Shang-Hsuan, Hsu, Pei-Chien, Sun, Yu-Yo, Lin, Teng-Nan, Shie, Feng-Shiun, Kao, Lung-Sen, Chou, Chih-Ming, Lee, Yi-Hsuan
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602016/
https://ncbi.nlm.nih.gov/pubmed/26865625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3457-15.2016
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