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Spinal Fbxo3-Dependent Fbxl2 Ubiquitination of Active Zone Protein RIM1α Mediates Neuropathic Allodynia through Ca(V)2.2 Activation

Spinal plasticity, a key process mediating neuropathic pain development, requires ubiquitination-dependent protein turnover. Presynaptic active zone proteins have a crucial role in regulating vesicle exocytosis, which is essential for synaptic plasticity. Nevertheless, the mechanism for ubiquitinati...

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Publicat a:J Neurosci
Autors principals: Lai, Cheng-Yuan, Ho, Yu-Cheng, Hsieh, Ming-Chun, Wang, Hsueh-Hsiao, Cheng, Jen-Kun, Chau, Yat-Pang, Peng, Hsien-Yu
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601949/
https://ncbi.nlm.nih.gov/pubmed/27629721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1732-16.2016
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