Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5)

Accurate prediction of the human pharmacokinetics (PK) of a candidate monoclonal antibody from nonclinical data is critical to maximize the success of clinical trials. However, for monoclonal antibodies exhibiting nonlinear clearance due to target-mediated drug disposition, PK predictions are partic...

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Publicado no:MAbs
Main Authors: Ahlberg, Jennifer, Giragossian, Craig, Li, Hua, Myzithras, Maria, Raymond, Ernie, Caviness, Gary, Grimaldi, Christine, Brown, Su-Ellen, Perez, Rocio, Yang, Danlin, Kroe-Barrett, Rachel, Joseph, David, Pamulapati, Chandrasena, Coble, Kelly, Ruus, Peter, Woska, Joseph R., Ganesan, Rajkumar, Hansel, Steven, Mbow, M. Lamine
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601564/
https://ncbi.nlm.nih.gov/pubmed/31068073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1615345
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