An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:MAbs
Päätekijät: Chung, Shan, Nguyen, Van, Lin, Yuwen Linda, Lafrance-Vanasse, Julien, Scales, Suzie J., Lin, Kevin, Deng, Rong, Williams, Kathi, Sperinde, Gizette, Li, Juan Jenny, Zheng, Kai, Sukumaran, Siddharth, Tesar, Devin, Ernst, James A., Fischer, Saloumeh, Lazar, Greg A., Prabhu, Saileta, Song, An
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2019
Aiheet:
Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601550/
https://ncbi.nlm.nih.gov/pubmed/30982394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1605270
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia