An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:MAbs
Hlavní autoři: Chung, Shan, Nguyen, Van, Lin, Yuwen Linda, Lafrance-Vanasse, Julien, Scales, Suzie J., Lin, Kevin, Deng, Rong, Williams, Kathi, Sperinde, Gizette, Li, Juan Jenny, Zheng, Kai, Sukumaran, Siddharth, Tesar, Devin, Ernst, James A., Fischer, Saloumeh, Lazar, Greg A., Prabhu, Saileta, Song, An
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601550/
https://ncbi.nlm.nih.gov/pubmed/30982394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1605270
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky