An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans

A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant to the FcRn-mediated immunoglobulin G (IgG) salvage...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Chung, Shan, Nguyen, Van, Lin, Yuwen Linda, Lafrance-Vanasse, Julien, Scales, Suzie J., Lin, Kevin, Deng, Rong, Williams, Kathi, Sperinde, Gizette, Li, Juan Jenny, Zheng, Kai, Sukumaran, Siddharth, Tesar, Devin, Ernst, James A., Fischer, Saloumeh, Lazar, Greg A., Prabhu, Saileta, Song, An
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601550/
https://ncbi.nlm.nih.gov/pubmed/30982394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1605270
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