Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy

Monoclonal antibody (mAb)-based blockade of programmed cell death 1 (PD-1) or its ligand to enable antitumor T-cell immunity has been successful in treating multiple tumors. However, the structural basis of the binding mechanisms of the mAbs and PD-1 and the effects of glycosylation of PD-1 on mAb i...

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Vydáno v:MAbs
Hlavní autoři: Liu, Hongchuan, Guo, Lijing, Zhang, Jing, Zhou, Yuehua, Zhou, Jinwei, Yao, Jian, Wu, Hai, Yao, Sheng, Chen, Bo, Chai, Yan, Qi, Jianxun, Gao, George F., Tan, Shuguang, Feng, Hui, Yan, Jinghua
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601540/
https://ncbi.nlm.nih.gov/pubmed/30892132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1596513
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