The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy

Programmed cell death 1 (PD-1)/PD-1 ligand-1 (PD-L1)-blocking monoclonal antibodies (mAbs) have taken center stage for tumor immune checkpoint therapy. Identification of the “hotspots” on PD-1 for mAbs will help to develop next-generation oral deliverable agents with long-lasting efficacy. Here, we...

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Publicado no:iScience
Main Authors: Chen, Danqing, Tan, Shuguang, Zhang, Hao, Wang, Haiyuan, He, Weiwu, Shi, Rui, Tong, Zhou, Zhu, Jianhua, Cheng, Hao, Gao, Shan, Chai, Yan, Qi, Jianxun, Xiao, Minghui, Yan, Jinghua, Gao, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6447726/
https://ncbi.nlm.nih.gov/pubmed/30952089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.03.017
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