Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies

Antibody-based PD-1/PD-L1 blockade therapies have taken center stage in immunotherapies for cancer, with multiple clinical successes. PD-1 signaling plays pivotal roles in tumor-driven T-cell dysfunction. In contrast to prior approaches to generate or boost tumor-specific T-cell responses, antibody-...

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Detalhes bibliográficos
Publicado no:Protein Cell
Main Authors: Tan, Shuguang, Chen, Danqing, Liu, Kefang, He, Mengnan, Song, Hao, Shi, Yi, Liu, Jun, Zhang, Catherine W.-H., Qi, Jianxun, Yan, Jinghua, Gao, Shan, Gao, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: Higher Education Press 2016
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5205664/
https://ncbi.nlm.nih.gov/pubmed/27815822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-016-0337-7
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