An unexpected N-terminal loop in PD-1 dominates binding by nivolumab

Cancer immunotherapy by targeting of immune checkpoint molecules has been a research ‘hot-spot' in recent years. Nivolumab, a human monoclonal antibody targeting PD-1, has been widely used clinically since 2014. However, the binding mechanism of nivolumab to PD-1 has not yet been shown, despite...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tan, Shuguang, Zhang, Hao, Chai, Yan, Song, Hao, Tong, Zhou, Wang, Qihui, Qi, Jianxun, Wong, Gary, Zhu, Xiaodong, Liu, William J., Gao, Shan, Wang, Zhongfu, Shi, Yi, Yang, Fuquan, Gao, George F., Yan, Jinghua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303876/
https://ncbi.nlm.nih.gov/pubmed/28165004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14369
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