Determinants for Neoantigen Identification

All tumors accumulate genetic alterations, some of which can give rise to mutated, non-self peptides presented by human leukocyte antigen (HLA) molecules and elicit T-cell responses. These immunogenic mutated peptides, or neoantigens, are foreign in nature and display exquisite tumor specificity. Th...

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Udgivet i:Front Immunol
Main Authors: Garcia-Garijo, Andrea, Fajardo, Carlos Alberto, Gros, Alena
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601353/
https://ncbi.nlm.nih.gov/pubmed/31293573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01392
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