ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

OBJECTIVE: Insulin suppresses adipose tissue lipolysis after a meal, playing a key role in metabolic homeostasis. This is mediated via the kinase Akt and its substrate phosphodiesterase 3B (PDE3B). Once phosphorylated and activated, PDE3B hydrolyses cAMP leading to the inactivation of cAMP-dependent...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Metab
Auteurs principaux: Stöckli, Jacqueline, Zadoorian, Armella, Cooke, Kristen C., Deshpande, Vinita, Yau, Belinda, Herrmann, Gaia, Kebede, Melkam A., Humphrey, Sean J., James, David E.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2019
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601125/
https://ncbi.nlm.nih.gov/pubmed/31105056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.05.002
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