Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide

In myelodysplastic syndromes with a partial deletion of the long arm of chromosome 5, del(5q), lenalidomide is believed to reverse anergic T-cell immunity in the bone marrow resulting in suppression of the del(5q) clone. In this study we used next-generation sequencing of immunoglobulin heavy chain...

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Publicat a:Haematologica
Autors principals: Mährle, Thorben, Akyüz, Nuray, Fuchs, Pim, Bonzanni, Nicola, Simnica, Donjete, Germing, Ulrich, Asemissen, Anne Marie, Jann, Johann Christoph, Nolte, Florian, Hofmann, Wolf-Karsten, Nowak, Daniel, Binder, Mascha
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601099/
https://ncbi.nlm.nih.gov/pubmed/30655375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.208223
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