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IFN-γ and TNF-α aggravate endothelial damage caused by CD123-targeted CAR T cell

Background: CD123-targeted chimeric antigen receptor (CAR) T cell (CART123) for the treatment of acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm has exhibited potential in clinical trials. However, capillary leakage syndrome, which is associated with endothelial cells d...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Sun, Yao, Wang, Shenyu, Zhao, Long, Zhang, Bin, Chen, Hu
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600319/
https://ncbi.nlm.nih.gov/pubmed/31417286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S205678
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