IFN-γ and TNF-α Synergize to Inhibit CTGF Expression in Human Lung Endothelial Cells

Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling. While the T-helper 1 (Th1) cytokine interferon-gamma (IFN-γ) is well characterized as immune-modulatory and anti-fibrotic cytokine, the...

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Bibliographic Details
Main Authors: Laug, Roderich, Fehrholz, Markus, Schütze, Norbert, Kramer, Boris W., Krump-Konvalinkova, Vera, Speer, Christian P., Kunzmann, Steffen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447888/
https://ncbi.nlm.nih.gov/pubmed/23029004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045430
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