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Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier
Rim2 is an unusual mitochondrial carrier protein capable of transporting both iron and pyrimidine nucleotides. Here we characterize two point mutations generated in the predicted substrate-binding site, finding that they yield disparate effects on iron and pyrimidine transport. The Rim2 (E248A) muta...
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| Gepubliceerd in: | Mitochondrion |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6599733/ https://ncbi.nlm.nih.gov/pubmed/30660752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2018.12.005 |
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