Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier

Rim2 is an unusual mitochondrial carrier protein capable of transporting both iron and pyrimidine nucleotides. Here we characterize two point mutations generated in the predicted substrate-binding site, finding that they yield disparate effects on iron and pyrimidine transport. The Rim2 (E248A) muta...

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Bibliographic Details
Published in:Mitochondrion
Main Authors: Knight, Simon A. B., Yoon, Heeyong, Pandey, Ashutosh K., Pain, Jayashree, Pain, Debkumar, Dancis, Andrew
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599733/
https://ncbi.nlm.nih.gov/pubmed/30660752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2018.12.005
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