DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

Fanconi anemia (FA) is a multigenic disease of bone marrow failure and cancer susceptibility stemming from a failure to remove DNA crosslinks and other chromosomal lesions. Within the FA DNA damage response pathway, DNA-dependent monoubiquitinaton of FANCD2 licenses downstream events, while timely F...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Liang, Fengshan, Miller, Adam S., Longerich, Simonne, Tang, Caroline, Maranon, David, Williamson, Elizabeth A., Hromas, Robert, Wiese, Claudia, Kupfer, Gary M., Sung, Patrick
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599204/
https://ncbi.nlm.nih.gov/pubmed/31253762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10408-5
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