Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes

Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that TLR4-induced responses are mediated by...

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Pubblicato in:Sci Rep
Autori principali: Alibashe-Ahmed, Mohamed, Roger, Thierry, Serre-Beinier, Veronique, Berishvili, Ekaterine, Reith, Walter, Bosco, Domenico, Berney, Thierry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599059/
https://ncbi.nlm.nih.gov/pubmed/31253838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45260-6
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