Efficient base editing for multiple genes and loci in pigs using base editors

Cytosine base editors (CBEs) enable programmable C-to-T conversion without DNA double-stranded breaks and homology-directed repair in a variety of organisms, which exhibit great potential for agricultural and biomedical applications. However, all reported cases only involved C-to-T substitution at a...

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Foilsithe in:Nat Commun
Main Authors: Xie, Jingke, Ge, Weikai, Li, Nan, Liu, Qishuai, Chen, Fangbing, Yang, Xiaoyu, Huang, Xingyun, Ouyang, Zhen, Zhang, Quanjun, Zhao, Yu, Liu, Zhaoming, Gou, Shixue, Wu, Han, Lai, Chengdan, Fan, Nana, Jin, Qin, Shi, Hui, Liang, Yanhui, Lan, Ting, Quan, Longquan, Li, Xiaoping, Wang, Kepin, Lai, Liangxue
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599043/
https://ncbi.nlm.nih.gov/pubmed/31253764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10421-8
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