Structure of the substrate-engaged SecA-SecY protein translocation machine

The Sec61/SecY channel allows the translocation of many proteins across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane. In bacteria, most secretory proteins are transported post-translationally through the SecY channel by the SecA ATPase. How a polypeptide is moved...

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Udgivet i:Nat Commun
Main Authors: Ma, Chengying, Wu, Xiaofei, Sun, Dongjie, Park, Eunyong, Catipovic, Marco A., Rapoport, Tom A., Gao, Ning, Li, Long
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599042/
https://ncbi.nlm.nih.gov/pubmed/31253804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10918-2
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