Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican gene expression and morphogenesis is disru...

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Pubblicato in:eLife
Autori principali: Diamantopoulou, Elvira, Baxendale, Sarah, de la Vega de León, Antonio, Asad, Anzar, Holdsworth, Celia J, Abbas, Leila, Gillet, Valerie J, Wiggin, Giselle R, Whitfield, Tanya T
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598766/
https://ncbi.nlm.nih.gov/pubmed/31180326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44889
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