A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice

Dengue virus (DENV) induces strong T and B cell responses upon infection. Hence, it is difficult to determine the contribution of cell-mediated immunity alone in the long lasting protection against DENV infection and disease. Numerous CD4+ and CD8+ T cell epitopes have been identified, mainly in the...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Roth, Claude, Cantaert, Tineke, Colas, Chloé, Prot, Matthieu, Casadémont, Isabelle, Levillayer, Laurine, Thalmensi, Jessie, Langlade-Demoyen, Pierre, Gerke, Christiane, Bahl, Kapil, Ciaramella, Giuseppe, Simon-Loriere, Etienne, Sakuntabhai, Anavaj
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598640/
https://ncbi.nlm.nih.gov/pubmed/31293584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01424
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