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An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

BACKGROUND: Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is becoming ever more apparent. It is therefore essential that studies are conducted to improve our understanding of the cellular ro...

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Dettagli Bibliografici
Pubblicato in:Neurobiol Dis
Autori principali: Connor-Robson, Natalie, Booth, Heather, Martin, Jeffrey G., Gao, Benbo, Li, Kejie, Doig, Natalie, Vowles, Jane, Browne, Cathy, Klinger, Laura, Juhasz, Peter, Klein, Christine, Cowley, Sally A., Bolam, Paul, Hirst, Warren, Wade-Martins, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Academic Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597903/
https://ncbi.nlm.nih.gov/pubmed/30954703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.04.005
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