A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Igf1 (insulin-like growth factor 1)

Insulin-like growth factor 1 (IGF1) is primarily synthesized in and secreted from the liver; however, estrogen (E2), through E2 receptor α (ERα), increases uterine Igf1 mRNA levels. Previous ChIP-seq analyses of the murine uterus have revealed a potential enhancer region distal from the Igf1 transcr...

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Vydáno v:J Biol Chem
Hlavní autoři: Hewitt, Sylvia C., Lierz, Sydney L., Garcia, Marleny, Hamilton, Katherine J., Gruzdev, Artiom, Grimm, Sara A., Lydon, John P., Demayo, Francesco J., Korach, Kenneth S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597841/
https://ncbi.nlm.nih.gov/pubmed/31073032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008759
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