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Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea

PIWI proteins are key regulators of germline and somatic stem cells throughout different evolutionary lineages. However, how PIWI proteins themselves are regulated remains largely unknown. To identify candidate proteins that interact with PIWI proteins and regulate their stability, here we establish...

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Pubblicato in:J Biol Chem
Autori principali: Wang, Chen, Yang, Zhen-Zhen, Guo, Fang-Hao, Shi, Shuo, Han, Xiao-Shuai, Zeng, An, Lin, Haifan, Jing, Qing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597837/
https://ncbi.nlm.nih.gov/pubmed/31076507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004445
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