Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis

During embryogenesis cells make fate decisions within complex tissue environments. The levels and dynamics of transcription factor expression regulate these decisions. Here, we use single cell live imaging of an endogenous HES5 reporter and absolute protein quantification to gain a dynamic view of n...

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Publicat a:Nat Commun
Autors principals: Manning, Cerys S., Biga, Veronica, Boyd, James, Kursawe, Jochen, Ymisson, Bodvar, Spiller, David G., Sanderson, Christopher M., Galla, Tobias, Rattray, Magnus, Papalopulu, Nancy
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597611/
https://ncbi.nlm.nih.gov/pubmed/31249377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10734-8
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