Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscillations of a...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:eLife
المؤلفون الرئيسيون: Phillips, Nick E, Manning, Cerys S, Pettini, Tom, Biga, Veronica, Marinopoulou, Elli, Stanley, Peter, Boyd, James, Bagnall, James, Paszek, Pawel, Spiller, David G, White, Michael RH, Goodfellow, Marc, Galla, Tobias, Rattray, Magnus, Papalopulu, Nancy
التنسيق: Artigo
اللغة:Inglês
منشور في: eLife Sciences Publications, Ltd 2016
الموضوعات:
Computational and Systems Biology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050025/
https://ncbi.nlm.nih.gov/pubmed/27700985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16118
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