Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscillations of a...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Phillips, Nick E, Manning, Cerys S, Pettini, Tom, Biga, Veronica, Marinopoulou, Elli, Stanley, Peter, Boyd, James, Bagnall, James, Paszek, Pawel, Spiller, David G, White, Michael RH, Goodfellow, Marc, Galla, Tobias, Rattray, Magnus, Papalopulu, Nancy
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Computational and Systems Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050025/
https://ncbi.nlm.nih.gov/pubmed/27700985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16118
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